Pathogenetic aspects of hypercoagulation and thrombotic readiness state development in cardiac patients and patients with malignant neoplasms

The objective of the review is to show the main links in the pathogenesis of hypercoagulation and thrombotic readiness state (TRS) in patients with cardiovascular pathology (coronary heart disease and/or arterial hypertension) and a burdened oncological anamnesis. A search was conducted using keywords in the text databases Scopus, Web of Science, PubMed for literary sources on factors associated with the development of hypercoagulation/TRS in cardiovascular pathology and a burdened oncological anamnesis. The state of thrombotic readiness (STH) is a collective concept that includes laboratory-detectable hypercoagulation, high levels of intravascular coagulation markers and clinical signs of pre-thrombosis (increased blood viscosity, permanent signs of organ dysfunction, etc. It has been proven that STH is more often diagnosed in patients with a cardiological profile with the addition of an aggravated oncologic anamnesis than in its absence. The potential danger of this condition lies in the risk of rapid progression with the development of disseminated intravascular coagulation (DIC syndrome). The relevance of this problem is due to the high incidence and mortality of patients with cardiovascular diseases (CVD) and malignant neoplasms. At the same time, in the available sources, when studying hypercoagulation abnormalities, due attention is not paid to comorbid patients and the risk of developing STH. The term hypercoagulable states is more common in the literature. However, further educational work is needed among doctors of different specialties regarding the prevention of STH development and possible complications due to the growing number of comorbid patients.