Study of the reactions of synthesis of 2-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisochinoline derivatives

The formation of 2-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline through stepwise synthesis reactions involving homoveratrylamine and p-nitro-, m-bromo-, o-methoxybenzaldehyde is described. The reaction stages include imine formation using a Dean-Stark apparatus, reduction in the presence of sodium borohydride, and cyclization in the subsequent stage in the presence of formalin and concentrated hydrochloric acid.