Causal deep learning to personalize medicine: Which intensive care patients with sepsis will benefit from corticosteroid therapy?
Corticosteroid treatment responders were those with severe metabolic acidosis and impaired circulation, whereas patients who were less ill based on these parameters were more likely to have increased mortality rates by corticosteroid treatment. There was also a notable discrepancy between the model's suggestions and the physicians' treatment that was carried out, implying improvements in the clinical assessment of patients with sepsis are necessary. Given recent years have not yielded new treatments for sepsis, computational clinical decision-support systems are worth exploring.
Institutions
- Amsterdam University Medical Centers (NL)
- Kantonsspital Aarau (CH)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Journal of Intensive Medicine
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1016/j.jointm.2025.07.002
- Primary Topic
- Geochemistry and Geologic Mapping
- Type
- article
- Field-Weighted Citation Impact
- 0.00