Homology Models of Salmonella Typhimurium Outer Membrane Proteins OmpV and LptE with Validation and Druggability Assessment

The proteins are OmpV (UniProt A0A634SAW8) and LptE (UniProt A0A5W2VQP4) from Salmonella. Models were generated with AlphaFold2/Swiss-Model (July 7, 2025), refined with ModRefiner, and validated with PROCHECK/ERRAT (July 13, 2025). Key quality scores: >97% residues in favored Ramachandran regions, GMQE scores of 0.79 (OmpV) and 0.88 (LptE). Druggability assessed with FPocketWeb, yielding scores of 0.998 (OmpV) and 0.758 (LptE). Keywords: Salmonella, OmpV, LptE, Homology Modeling, AlphaFold2, PROCHECK, ERRAT, FPocket, Druggability, Outer Membrane Protein, Computational Biology.