Survival Analysis and Prognostic Factors of Endometrial Cancer- RegionalCancer Centre Experience

with rising incidence globally, especially in Asia. Prognosis depends on multiple clinicopathological factors, buttheir relative impact on survival remains to be fully clarified.Aim: To analyze survival outcomes and identify independent prognostic factors affecting overall survival inpatients with endometrial cancer treated at our institute (Regional Cancer Center).Methodology: This retrospective ‘observational study included 166 patients treated at the Department ofGynecologic Oncology, Kidwai Memorial Institute of oncology and research institute, Bangalore, between 2014and 2019. Clinical, pathological, treatment, and follow-up data were analyzed. Survival was estimated usingKaplan-Meier methods, and prognostic factors were assessed by’ Cox ‘regression analysis.Results: The majority (86.1%) had endometrioid histology with significantly better mean overall survival (83.98months) compared to non-endometrioid tumors (50.21 months, p=0.000). Higher tumor grade and presence oflymphovascular space invasion (LVSI) were associated with poorer survival (p=0.000). LVSI showed a more thanfourfold increased risk of mortality (HR 4.736, p=0.002). Older age (≥70 years) also’ predicted worse outcomes(HR 2.593, p=0.037). Advanced stage correlated with decreased survival (p=0.000). Myometrial invasion andlymph node involvement were not independent predictors in multivariate analysis. Conclusion: Histological subtype, ‘tumor grade, LVSI status, age, and stage significantly influence survival inEC patients. LVSI and age are strong independent prognostic markers and should be integral to risk stratificationand personalized treatment planning to improve outcomes.