STRUCTURAL CHANGES IN THE KIDNEYS OF HIGHLY EMOTIONAL RATS WITH EXPERIMENTAL NEPHROLITHIASIS

Urolithiasis continues to occupy a leading position in the daily practice of urologists. The relevance of studying this disease is determined by its wide global prevalence (affecting at least 3% of the world’s population) and the fact that it occurs most frequently in working-age individuals, particularly between 40 and 50 years of age [4]. According to Russian and international authors, the prevalence of urolithiasis worldwide ranges from 4% to 10%, while recurrence rates reach up to 50%. In the structure of urological inpatient facilities, this pathology accounts for up to 40% of patients, with as many as 70% being admitted on an emergency basis. The proportion of patients varies between 5% and 10% across different world regions, depending on geographic, racial, and ethnic factors [3]. According to Russian researchers, the prevalence of urolithiasis in different regions of the country ranges from 3.5% to 9.6% of the population, with an overall increase in incidence by 17.3% in recent years, which in absolute terms reaches 738,130 cases [1].