Systemic inflammation and risk of chorioamnionitis-related preterm birth: a single-center retrospective analysis

Aim - to assess the predictive value of systemic inflammatory markers for chorioamnionitis in women with preterm birth. Materials and methods. This single-center retrospective cohort study included 198 cases of preterm delivery (<37 weeks) at Kyiv City Maternity Hospital No.5 during 2022. Data were extracted from electronic medical records. Multivariate logistic regression was used to analyze associations between histologically confirmed chorioamnionitis and clinical/laboratory indicators. Results. Elevated maternal leukocyte count emerged as the strongest independent predictor of chorioamnionitis. Increased C-reactive protein levels also demonstrated significant predictive power. Other variables, such as cervical length, procalcitonin, and psycho-emotional state, lost significance after adjustment. The ROC curve showed good model discrimination (AUC=0.747). Conclusions. Systemic inflammatory markers, especially leukocytosis and C-reactive protein, play a key role in predicting chorioamnionitis and may improve early risk screening for preterm birth. The study was conducted in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution cited in the manuscript, and written informed consent was obtained from all participants. The authors declare no conflicts of interest.