An Overview of Keratitis and Its Treatment with Antiviral Cubosomal Insitu Gel

Keratitis, is an inflammatory condition of the cornea often caused by viral infection such as Herpex Simplex Virus, poses a substantial impact on your therapy due to poor drug bioavailability and rapid tears clearance. Usually, eye drops are affected with poor ocular retention time and limited corneal penetration, reducing therapeutic efficacy. Advanced drug delivery system such as cubosomes and insitu gel rose as a breakthrough approach to overcome the limitations. Hydrophilic and hydrophobic and amphiphilic drug can be encapsulated into a lipid-based nanovesicle called cubosomes which offers targeted controlled release and protection against drug degradation. In cubosomal insitu-gel, the drug loaded cubosome are further incorporated into insitu gel which undergoes phase transition upon contact with ocular physiological triggers (pH, temperature and ions) enhance drug retention and patient compliance by transforming into a viscous gel in the eye which exhibits improved corneal permeation and sustained drug release compared to conventional formulation.