Formulation and Evaluation of Cefuroxime Axetil

Emulgels, a hybrid system combining emulsions and gels, offer an innovative approach to topical delivery, especially for hydrophobic drugs. The present work aimed to investigate the potential of Emulgel in enhancing the topical drug delivery of Cefuroxime Axetil using different gelling agents. The solubility studies were performed to for the suitable oils, surfactants, through which caproyl 90 was taken as oil, Labrasol ALF as oil phase surfactant and tween 80 as aqueous phase surfactant and Carbopol 940, HPMC and methylcellulose as gelling agents were selected. The influence type of gelling agent and the concentration of both the oil and emulsifying agent on the drug release from the formulated Emulgel was studied showing a 8hrs drug release. The prepared formulation was evaluated for their physical appearance, pH determination and in-vitro release study. The prepared emulgel was showed acceptable physical properties concerning color, homogeneity, consistency and pH value and it also showed desirable drug release during invitro diffusion studies and the microbiology studies were also performed showing inhibitory zone. The formulation has been subjected to accelerated stability condition, where there is no declined release of drug.