Optimization and appraisal of Bi-layered tablets containing divalproex sodium to augment therapeutic effectiveness

The current study aimed to optimize and evaluate bi-layered tablets of Divalproex Sodium designed for improved therapeutic effectiveness in the treatment of epilepsy, bipolar disorder, and migraine. The formulation combined an immediate release (IR) layer with a sustained release (SR) layer to ensure rapid onset and prolonged action. Compatibility studies confirmed no significant interaction between the drug and excipients. Evaluation of pre- and post-compression parameters including hardness, friability, drug content, and in vitro dissolution studies demonstrated desirable characteristics. The IR layer achieved 97.31% drug release within 30 minutes, while the SR layer sustained release up to 96.34% over 960 minutes. Stability studies over 56 days confirmed the physical and chemical integrity of the formulation. These findings support the feasibility of bi-layered tablets of Divalproex Sodium as an effective delivery system for managing neurological disorders.