Analysis of Significantly Upregulated Genes in Esophageal Cancer Tissues and Their Impact on Patients’ Survival Prognosis Based on the GEPIA Database

[Objective] This study investigated upregulated genes in esophageal cancer using the GEPIA database and analyzed their prognostic value. [Methods] Differentially expressed genes between esophageal cancer and normal tissues were identified in GEPIA. The top candidates were validated and subjected to survival analysis to assess associations with patient outcomes. [Results] A total of 4049 genes were significantly upregulated in esophageal cancer tissues. The top 10 genes included POU2F1, HOXB7, RPPH1, RPL41P2, EIF2AK2, ADH1B, LCLAT1, and SNX10. Among them, only RPPH1 showed prognostic relevance, being significantly associated with disease-free survival, though not with overall survival. The remaining genes did not demonstrate significant survival correlations. [Conclusion] RPPH1 is a potential prognostic biomarker for esophageal cancer, with high expression linked to poor disease-free survival. These findings highlight its value as a therapeutic target and provide insights for individualized treatment strategies.