Quinazoline Based Molecular Hybrids as Potential Therapeutic Agents in Tumour Therapy

Quinazoline and quinazolinone containing compounds are important class of nitrogen containing heterocyclic compounds having diverse therapeutic activities. A variety of marketed drugs containing these moieties are available now and these compounds have been reported to exhibit a wide spectrum of biological functions. Their synthetic feasibility and versatility in structural alterations and fictionalization adds their allure in medicinal chemistry. It is interesting that the anticancer activity of these compounds is more projected. However, their activity is not only restricted to single cancer target. Therefore, it is very interesting to explore quinazoline and quinazolinone based compounds having immense therapeutic potential on multiple cancer targets. A recent update on various quinazoline derivatives acting on different molecular targets for cancer treatment has been combined in this review.