Risk of Aedes Aegypti as Biological Vector Transmissibility between Dengue Virus and Heartworm: Impact on the Pathogenesis of Zoonotic Diseases in Rural and Urban Environments

Dengue is a vector-borne viral disease caused by the flavivirus dengue virus (DENV) that continue to circulate worldwide. A positive-stranded enveloped RNA virus (DENV) is principally transmitted by Aedes mosquitoes. It has four antigenically distinct serotypes, DENV-1 to DENV-4. This review highlights pathophysiology and clinical signs of Dengue Virus correlated with Heartworm Disease by Aedes aegypti mosquitoes, which transmit Dengue, Zika, Chikungunya and other arboviruses, had been modified genetically which carries a Wolbachia pipientis bacterium that stops the insect from transmitting viruses. There have been recent advances in the development of therapeutic drugs, and vaccines that are currently being pursued at several phases of preclinical and clinical development. The preventive measures of dengue transmission and challenging the epidemiological surveillance of the zoonotic diseases are the key role to control the spread of this vector through the improve the health promotion campaigns in water supply, personal protection, biological and mechanism vector approaches.