Assessment and comparison of radiation dose on the liver function tests for Breast and Lung cancer patients during radiotherapy

The purpose of this study was to examine how radiation therapy affects biochemical changes in breast and lung cancer patients in Al-Najaf Governorate. Thirty cancer patients participated in the study: fifteen who received between one and seven doses of radiation therapy, and fifteen who received more than five doses. Radiation therapy was administered as the treatment. In addition, twenty-five healthy individuals (thirteen men and twelve women) were included as a control group. The investigation was conducted from February to November 2023 at the National Oncology Teaching Hospital in Najaf City. Based on the blood parameters, both male and female patients who underwent radiation therapy showed lower levels of hemoglobin, red blood cells, white blood cells, and platelets. With regard to liver enzymes, both male and female patients with cancer showed elevated levels of AST and ALT. For the ALP enzyme, no significant sex-based differences were observed, but an overall increase was noted. In terms of bilirubin, noticeable changes were detected, including increases in both direct and total bilirubin levels.