Synthesis of optically pure 3-heteroaryl-2-methylpropanoic and 3-heteroarylbutanoic acids by biocatalytic resolution

A new approach has been developed for synthesizing compounds with potential biological activity − enantiomerically pure 3-heteroaryl-2-methylpropanoic and 3-heteroarylbutanoic acids. The enzymatic dynamic kinetic enzymatic resolution methodology was applied at key synthesis stages. A dual biocatalytic purification method was employed to achieve a high degree of optical purity of the obtained products. The resulting amines are promising building blocks for the development of new pharmaceuticals and biologically active compounds