Association between Serum Uric Acid and Blood Pressure in Overweight and Obese Children and Adolescents: A Multicenter Study

Childhood overweight and obesity are recognized as modifiable risk factors for the development of hypertension; however,the role of serum Uric Acid (UA) remains unclear. This study evaluated the association between UA and blood pressure in 173overweight or obese patients aged 5-18 years (mean age 11.7 ± 2.9 years; 36.4% female). Among them, 28.9% were overweightand 71.1% obese. Mean UA level was 5.1 ± 1.2 mg/dL. Elevated UA, defined as above the population mean or greater than twoStandard Deviations (SD) above the mean, was significantly associated with White-Coat Hypertension (WCH). Specifically,UA > mean was associated with WCH (OR =7.8, 95% CI 1.1-62.1; p=0.04) and UA > mean + 2 SD demonstrated a strongerassociation (OR =9.2, 95% CI 2.8-30.1; p<0.001). Our data supports the association between elevated UA and WCH.