Solubility Enhancement of Carvedilol Polymeric Nanoparticles by Nanoprecipitation Technique

Abstract: Carvedilol is an anti-cancer drug which is used in treatment of breast cancer. But it has poor water solubility property. The research work is based on improvement of solubility by formulation and development of polymeric nanoparticles by nanoprecipitation technique. HPMC K 15M is used as polymer and Poloxamer 407 is used as surfactant. After pre formulation study the drug interaction study is performed by FTIR and DSC analysis. After preparation various evaluation methods are adopted as per the specification. The in vitro drug release study and stability study shows F6 formulation produce good entrapment capacity. The result of various kinetic studies is also acceptable. So we concluded that HPMCK15M is the appropriate polymer and Poloxamer 407 is the appropriate surfactant and nanoprecipitation is the best technique to enhance the stability of and able to enhance the anti-cancer activity.