Premature ovarian insufficiency (POI): guideline of European society of human reproduction and embryology – 2024

<p>This updated guideline offers best practice recommendations for the care of women with both primary and secondary premature ovarian insufficiency (POI). POI is a clinical condition defined by the loss of ovarian function indicated by irregular menstrual cycles together with biochemical confirmation of ovarian insufficiency before the age of 40.<br>Women with POI have unique needs. They may not only suffer from symptoms associated with estrogen deficiency, but can also experience other issues, with a significant impact on their quality of life and later health outcomes. POI can have significant effects on fertility, bone health, cardiovascular health, sexual function, psychological health and neurological function.<br>The impact of POI on these different domains and the treatment options for each along with monitoring needs where relevant are all discussed in the guideline.<br>In addition to hormone therapy the guideline also covers non-hormonal and complementary treatments, lifestyle interventions and puberty induction.<br>This guideline is an updated version and replaces the ESHRE Guideline on the management of women with POI (2016).</p>