Stealth Liposomal Gel of Desonide: Formulation and Evaluation

The present study focused on the design and evaluation of a stealth liposomal gel containing Desonide intended for topical application. Desonide, a corticosteroid, is commonly prescribed for treating inflammatory skin conditions such as psoriasis. Stealth liposomes were developed via the thin-film hydration technique using cholesterol, soya lecithin, and PEG, and were subsequently incorporated into a gel matrix formulated with Carbopol. The prepared liposomal gel was evaluated for its physicochemical characteristics including particle size, zeta potential, entrapment efficiency, and in vitro release behavior. Among the various formulations, the optimized batch (F3) exhibited a mean particle size of 238.9 nm, a zeta potential of –44.62 mV, and a drug entrapment efficiency of 76.42%. In vitro release studies confirmed a controlled drug release profile extending up to 4 hours. The developed formulation demonstrated improved stability, enhanced drug encapsulation, and sustained release, indicating its potential as a promising carrier for effective topical corticosteroid delivery