Perfection of Wound Healing to Win the War on Cancer

The objective of this article is to find a right approach to win the war on cancer. To win the war on cancer, it is necessary to establish a valid concept of cancer to confront cancer successfully. Cancer evolves due to wound unhealing, which was a valid concept introduced by Virchow in 1858. Cancer establishments pursued cancer therapies by a commanding principle of creating wound to kill cancer cells (CCs) exactly opposite to the Virchow’s advice, resulting in the failure to win the war on cancer. We have unknowingly pursued cancer therapy following the guidance of Virchow’s wound healing through employment of wound healing metabolites purified from urine which we named cell differentiation agnet-2 (CDA-2) to produce excellent cancer therapy. CDA-2 is the only drug best to handle the issue of cancer stem cells (CSCs). CSCs became known in 1997. The discovery of CSCs unraveled CSCs as the most important issue of cancer to reveal CSCs as the cells to initiate tumor growth and the cells to contribute to the most fatal effects of cancer. Fatal effects of cancer such as metastasis, drug resistance, anti-apoptosis, angiogenesis, unresponsiveness and recurrence are all attributable to CSCs. The nature creates chemo-surveillance as a defense mechanism to guard the pathological build-up of CSCs and CCs by destabilizing abnormal methylation enzymes (MEs) which are the driving cause of CSCs and CCs. CDA formulations are the right drugs to turn off abnormal MEs to win the war on cancer.