Inverse‐Electron‐Demand Diels–Alder Reaction Involving Indole Scaffold and Its Derivatives

ABSTRACT The significant biological and therapeutic potential of indole compounds has generated attention and necessitated the development of improved methodologies for their efficient synthesis. This review emphasizes the significant advancements in the synthesis of various indole‐based six‐membered cycloadducts via the inverse‐electron‐demand Diels–Alder reaction, an effective method yielding highly substituted and enantioenriched products as both dienes and dienophiles for the period 2010–2025. Furthermore, several essential examples of DFT investigations have been incorporated to examine the most favored mechanistic approaches during the corresponding procedures.