Dynamics of indicators of organ dysfunction and C-reactive protein in donors with brain death

Conditioning of functional systems and proper medical support of a potential donor must necessarily include timely assessment, rapid recognition and elimination of organ dysfunction and functional system failure. The aim of the study was to investigate the dynamics of organ dysfunction indicators and C-reactive protein (CRP) in brain-dead donors. Materials and methods. The prospective study included 106 brain-dead organ and/or tissue donors who underwent intensive care in the anesthesiology and resuscitation departments of the Mogilev region from 01.01.2020 to 1.11.2023. Results. In deceased donors statistically significant increase in CRP was observed from day 1 to day 4 of intensive care: in day 1d – 13.3 (3.86; 29.1) mg/l, 2d – 85 (45.4; 140.6) mg/l (p < 0.0001 vs 1d), 3d – 135.3 (73.6; 238.2) mg/l (p < 0.0001 vs 2d), 4d – 219.7 (112.7; 326.4) mg/l (p < 0.0001 vs 3d). On days 5–7, CRP level did not change statistically significantly. A moderate correlation was found between the CRP level and the level of creatinine (R = 0.37), urea (R = 0.34), total protein (R = –0.32), cholesterol (R = –0.27). From day 1 to day 4, potential donors showed a statistically significant decrease in the concentration of total protein and cholesterol. Also, on days 2 to 6, there was an increase in the level of creatinine and urea compared to the initial level. Conclusion. CRP in organ and tissue donors can be used as a quantitative cumulative indicator of the presence of a systemic inflammatory response and multiple organ dysfunction.