Clinical Evaluation of Reptile Gel manufactured by WBCIL: Vasodilation, Temperature Modulation, and Improved Penile Blood Flow

Reptile Gel, developed by West Bengal Chemical Industries Ltd., Kolkata, India (WBCIL) is a novel, drug-free topical formulation for erectile dysfunction (ED) that promotes localized vasodilation via an evaporative cooling–warming mechanism. Building upon our earlier findings (first clinical trial) of biphasic thermal responses linked to microcirculatory enhancement, this second clinical trial aimed to directly assess its effects on arterial blood flow using Doppler ultrasonography. Eight healthy male participants (aged 35–52 years) were selected for this trial, and they applied Reptile Gel under standardized conditions following a negative patch test for all of them. Peak Systolic Velocity (PSV) was measured in the common, internal, and external carotid arteries, as well as the posterior tibial artery, before and after application. Results demonstrated a consistent and significant increase in PSV across all participants, with an average rise of 30.3 cm/s, confirming enhanced arterial inflow. Parallel monitoring of skin surface temperature revealed a biphasic response—an initial cooling effect followed by sustained warming—corroborating vasodilatory activity. No adverse effects were observed. These findings provide compelling evidence that Reptile Gel enhances peripheral and penile haemodynamics, supporting its potential as a safe, non-invasive therapeutic option for managing vasculogenic ED.