Effect of Bryophyllumpinnatumon Indomethac in Induced Gastric Ulcer in Wistar Rat

Bryophyllumpinnatum commonly known as Miracle Leaf belongs to the family of Crassulaceae. It has been widely used as a traditional medicine for the treatment of various ailments, including gastrointestinal disorder.This study evaluated the effects of Bryophyllumpinnatum (Miracle Leaf) on indomethacin-induced gastric ulcers in Wistar rats, focusing on ulcer counts, immunoglobulin levels, and histopathologicalchanges. A total of fifty-two rats were used for the study and were divided into pre-treatment and post-treatment groups, both having six subgroups. Each group received aqueous Bryophyllumpinnatum extract as follows; low dose (250 mg/kg), medium dose (500 mg/kg), high dose (1000 mg/kg), Rabeprazole for the positive control and distilled water for the negative control.Results showed that Bryophyllumpinnatum significantly reduced ulcer counts in both pre-treated and posttreated groups in a dose-dependent manner, with the high dose (1000mg/kg) achieving the lowest ulcer count for pre-treatment and post-treatment surpassing Rabeprazole. Immunoglobulin analysis revealed significant modulation, with reductions in iimmunoglobulin E (IgE) levels and normalization of IgG, IgA, IgM, and IgD levels, particularly at the highest dose.These findings suggest that Bryophyllumpinnatum possess ulcer healing properties