Exploring The Overview on Investigation of Isatin Hybrids as Potential Cancer Cell Degrader

Isatin (1H indole 2,3-dione), one of the heterocyclic scaffold, identified in humans and various plant species. Isatin and its derivatives are synthesized synthetically by many researchers due to its diverse pharmacological actions like anticancer, anti-TB, antimicrobial, antifungal, antioxidant, anti-inflammatory, anti-HIV etc. Based on the literature surveys, confirms the profile of isatin derivatives and their pharmacological importance. This review represents the development of novel isatin analogues as a potent chemotherapeutic agent. Structural modification of isatin by substitution at position N, carbonyl groups at position 2 and 3 leads to the development of biologically potential analogues. It also include the evidence of various literature surveys. Discovery of new isatin hybrid molecule via hybridization is one of the approach to overcome drug resistance, improve efficiency, reduce toxicity and enhance specificity. Structural activity relationship also represents provide the development of novel isatin analogues having potent activity and less toxicity. This can be utilised for future development of novel derivatives.