On a Reaction-Diffusion System Describing Cell Interactions with a Medical Drug

In this paper, we study a nonlinear problem modeling the interaction between a chemotherapeutic drug and the normal, tumor, and immune cells. The macroscopic model for various cell densities and a medical drug is governed by a nonlinear reaction-diffusion system. We first derive some a priori estimates and then establish the global existence of a bounded solution for the nonlinear system. Finally, we study the long-time behavior of the solution for the model problem. These results will provide a theoretical foundation for scientists in the health and medical sciences to design an optimal drug dosage for cancer patients during a treatment when using a chemotherapeutic drug.

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Publication Details

Journal
Communications on Pure &amp Applied Analysis
Published
2025-09-15
DOI
https://doi.org/10.3934/cpaa.2025092
Primary Topic
Geochemistry and Geologic Mapping
Type
article
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article

On a Reaction-Diffusion System Describing Cell Interactions with a Medical Drug

Communications on Pure &amp Applied Analysis
Geochemistry and Geologic Mapping
article

On a Reaction-Diffusion System Describing Cell Interactions with a Medical Drug

article en

Abstract

In this paper, we study a nonlinear problem modeling the interaction between a chemotherapeutic drug and the normal, tumor, and immune cells. The macroscopic model for various cell densities and a medical drug is governed by a nonlinear reaction-diffusion system. We first derive some a priori estimates and then establish the global existence of a bounded solution for the nonlinear system. Finally, we study the long-time behavior of the solution for the model problem. These results will provide a theoretical foundation for scientists in the health and medical sciences to design an optimal drug dosage for cancer patients during a treatment when using a chemotherapeutic drug.

Communications on Pure &amp Applied AnalysisVol. 25(0)
Washington State University (US)
Openalex Percentile: Top 39%
Geochemistry and Geologic Mapping
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