Clinical and microbiological features of pneumonia caused by klebsiella pneumoniae in patients with pulmonary tuberculosis

A retrospective observational “case-control” study was conducted on 80 cases of pneumonia associated with K. pneumoniae, including 40 cases (main group) in patients with tuberculosis (TB) of the respiratory organs and 40 cases in those without TB (comparison group). Each patient of the main group was matched with a patient of the comparison group of the same gender and age group. The article presents the results of the study of clinical and laboratory data of patients, sensitivity of isolated K. pneumoniae strains to antibiotics (AB). Among comorbidities, TB patients with Klebsiella pneumoniae co-infection more often had a history of HIV infection and chronic alcoholism, 27.5 % of patients had no complaints. 72.5 % of patients of the main group and all patients (100 %) of the comparison group noted deterioration of health associated with pneumonia onset (χ 2 = 12.75, p < 0.001). Most patients in the comparison group noted cough (χ 2 = 12.58, p < 0.001) and fever (χ 2 = 4.94, p = 0.026). Other complaints found in patients of both study groups had no statistically significant differences. The isolated strains of K. pneumoniae are characterized by a high level of resistance to aminopenicillins, respiratory fluoroquinolones, carbapenems; meanwhile have 100 % sensitivity to colistin and fosfomycin, tigecycline, amikacin was noted.