Nano-Biosensor based on QDs for Ultrasensitive Detection of N-Methylamphetamine in urine samples

In modern analytical chemistry, designing and fabricating various nano-biosensors based on quantum dots (QDs) is an interesting topic for the sensitive and rapid detection of different analytes. Sensitive detection of illicit drugs is important for maintaining global health. Among these drugs, rapid and easy detection of N-Methylamphetamine in urine is important due to its widespread abuse among young people. In this work, the ligand exchange method was used to perform the surface modification of CdTe QDs with a specific aptamer. The size and morphology of the nano-biosensor were characterized by TEM and DLS. The prepared nano-biosensor had a spherical morphology and a size of about 5 nm. The prepared nano-biosensor is capable of measuring N-Methylamphetamine with a detection limit of 0.4 nM in real urine samples.