MUCOADHESIVE BUCCAL FILMS: ENHANCING DRUG DELIVERY THROUGH MUCOSAL SURFACES

Mucoadhesive buccal films are innovative drug delivery systems designed for effective local and systemic therapeutic action via the oral mucosa. This review explores anatomical, physiological, and formulation factors that influence their performance. Key advantages include bypassing hepatic first-pass metabolism, enhanced bioavailability, patient compliance, and controlled drug release. The article details mechanisms of mucoadhesion, polymers, plasticizers, and manufacturing techniques such as solvent casting and hot-melt extrusion. Evaluation parameters, including mechanical strength, drug content, and in vivo residence time, are outlined. Despite formulation challenges, recent advances in nanoformulations and hybrid films offer promising prospects for commercial and clinical applications.