Formulation And Evaluation of Anthralin Nano Particle Loaded Shampoo for Alopecia Areata

The physical, mental and social dimensions of life are negatively affected by alopecia areata and can be greater than those resulting from life-threatening disease like myocardial infarction. Therapeutic concentration of anthralin should reach to deeper epidermal regions to exert effect on mitochondrial function and structure but most of conventional creams fail to do so. Method at laboratory scale: Chitosan nanoparticle prepared by melt emulsification. This method is fast, feasible in laboratory scale; avoid use of organic solvent and highly reproducible. A combination of surfactants had been taken to offer electrostatic repulsion and steric stabilization which is necessary to maintain physical stability of chitosan nanoparticle. NLC formulation had higher drug retention in comparison to chitosan nanoparticle after storage up to 06 months due to its amorphous nature. Recent formulation development initiatives including our investigation have validated utility of chitosan nanoparticle in topical drug delivery at least in case of anthralin.