Synthesis and Characterization of Novel Benzoxazole Schiff Base Derivatives

The synthetic work in this study was successfully carried out as planned, with all reactions yielding the expected compounds. A series of 2-(2-arginomethylene)hydrazyl)benzo[d]oxazole derivatives was synthesized using appropriate synthetic routes. The newly obtained compounds and intermediates were purified through recrystallization or column chromatography and further characterized using various physical and spectral techniques. Infrared (IR) spectroscopy showed characteristic peaks at 2795.34 cm⁻¹, 2908.97 cm⁻¹, 2713.33 cm⁻¹, 1660.90 cm⁻¹, and 1594.92 cm⁻¹. Proton NMR analysis displayed signals at δ 10.58 (NH), 8.55, 7.39, 8.78, 8.59, and 7.72 ppm. Mass spectral analysis confirmed the molecular ion peak at m/z 327, supporting the proposed molecular structure. Thin-layer chromatography (TLC), IR, ¹H-NMR, and mass spectra collectively confirmed the successful synthesis of benzoxazole Schiff base derivatives. Among the derivatives, the compound containing 2,4-dinitrobenzaldehyde exhibited particularly promising physical and spectral properties, suggesting its potential significance.