Innovative Formulations in Pharmacology: From Nanoemulsions to Controlled Drug Delivery

Abstract Preclinical toxicology plays a pivotal role in the safety evaluation of novel therapeutic agents. The evolving landscape of toxicological assessments necessitates integration between in vitro, in vivo, and translational approaches. This review outlines key advancements in preclinical toxicology, focusing on emerging technologies such as organ-on-a-chip systems, improved animal models, and computational toxicology and overview of innovative formulations in pharmacology, focusing on nanoscale drug delivery systems, novel drug delivery technologies, and future directions in drug formulation.. The article also discusses key technologies like high- pressure homogenization, nanoemulsions, and supercritical fluid techniques have significantly advanced the field, enabling the creation of stable and effective formualtion and also translational challenges and regulatory perspectives, aiming to provide a comprehensive understanding of how modern strategies are bridging gaps between laboratory studies and clinical safety.