Enhanced phototherapeutic effects of laser-irradiated Ag NPsdecorated TiO2 Nanotubes in colon cancer cells

Silver nanoparticles (Ag NPs) successfully decorated on titanium dioxide (TiO2 ) nanotubes (NTs). The effect of Ag NPs decorated TiO2 NTs on colon cancer cells (SW480 cells) is investigated with/without laser exposure at 532 and 808 nm in different times and various concentrations (15.6, 31.25, 62.5, 125, 250, 500μg/ mL). The aims to determine different doses and effective concentrations of Ag NPs-decorated TiO2 for low-energy laser treatment. Colon cancer (SW480) cells y was conducted for the green laser (=532 nm, power=300 mW) and NIR laser rays (= 808 nm, power=150 mw). The untreated cells (control group) maintain a high level of viability across all concentrations of Ag NPs decorated TiO2 NTs. The results indicate that the treatment with Ag NPs-decorated TiO2 NTs and green laser significantly reduced the cancer cell viability in a dose-dependent manner. This study demonstrates the potential of Ag NPs-decorated TiO2 NTs as a novel nanomaterial for photothermal therapy of colon cancer. This approach has several advantages over conventional therapies, including minimal invasiveness, and reduced side effects.