Integrating Ki-67 and Treatment Strategies to Guide Prognosis in High-Grade Meningiomas: A Multivariable Analysis of Prognostic Factors in WHO Grade II/III Meningiomas

Introduction High-grade meningiomas (WHO Grade II/III) are associated with high recurrence rates and poor survival despite aggressive therapy Adjuvant radiotherapy’s (RT) benefit after gross total resection (GTR) remains uncertain and histopathologic markers such as Ki-67 may further refine risk stratification and inform postoperative management AIM: to identify the role of RT and clinicopathologic predictors of local failure-free survival (LFFS) and overall survival (OS) in high-grade meningiomas