Antibiotic Resistance of Selected Bacterial Pathogens Causing Respiratory Infections at Tay Nguyen University Hospital in 2025

Objective: To evaluate the antimicrobial susceptibility of bacterial pathogens isolated from respiratory tract infections at Tay Nguyen University Hospital. Methods: Bacterial isolates were tested using the Kirby–Bauer disk diffusion method on Mueller–Hinton agar, interpreted according to CLSI 2023 guidelines. Results: Streptococci: High resistance to Erythromycin (80.5%), Vancomycin (70.7%), Ampicillin (68.3%), and Tetracycline (65.9%); susceptible to Levofloxacin (70.7%) and Ofloxacin (65.9%). Pseudomonas aeruginosa: Resistant to Amikacin (67.9%), Levofloxacin (57.1%), and Ofloxacin (53.6%); Piperacillin/Tazobactam showed highest susceptibility (75%). Staphylococcus aureus: Strong resistance to Erythromycin (87.0%) and Tetracycline (71.4%); Amikacin remained effective (97.8%). Conclusion: Respiratory pathogens exhibited high resistance to common antibiotics, notably Macrolides and Tetracyclines. Continuous surveillance and antibiotic stewardship are necessary for effective treatment.