Anti-Alzheimer's Activity of Bacopa Monniera Extract on Monoamines in AD Induced Albino Mice

The aim of the study is to investigate the anti-Alzheimer’s activity of Bacopa monniera extract(BME) on Monoamines (Dopamine, Norepinephrine and Epinephrine) in AD induced mice with reference to Morphometric and Behavioural aspects. Male Albino mice(Mus musculus) of one month old weighing 20±2 grams, used as experimental model and were maintained according to ethical guidelines for animal protection and welfare. Mice were divided into four groups as follows: Group I: Control mice; Group II: mice treated with BME; Group III (AD induced): mice treated with D-Gal & NaNO2; Group IV: AD induced mice simultaneously treated with BME. Changes in behavioural aspects of four groups of mice were analyzed by using Morris Water Maze technique. Dopamine(DA), Norepinephrine(NE) and Epinephrine(EP) contents were determined in brain regions of all groups of mice at selected time intervals through standard biochemical assay techniques. From the results, it was obvious that BME showed positive effects on body weight, learning skills, memory and concentration, whereas D-Gal and NaNO2 caused learning and memory deficits in mice which could be ameliorated by simultaneous administration of BME. Similarly, protective effects of BME were noticed on Dopamine, Norepinephrine and Epinephrine of mice brain wherein, oral administration of BME in AD induced mice could revert the changes to normal levels. From these observations, it was inferred that BME had potential compounds which can prevent learning and memory deficits effectively and thus confer neuroprotection against Alzheimer’s disease.