IMPORTANCE OF PHARMACOVIGILANCE AND SIGNAL DETECTION IN POST MARKETING SURVEILLANCE FOR DRUG SEFETY

The primary goal of postmarketing surveillance is to provide information for risk assessment of a drug. Drugs affecting the central nervous system form a unique group of products for surveillance because they are often misused, abused, and diverted. These medications include opioid analgesics, stimulants, sedativehypnotics, muscle relaxants, anticonvulsants and other drug classes. Their adverse events are difficult to monitor because the perpetrator often attempts to conceal the misuse, abuse and diversion of the product.