Effects of citrus essential oils on growth kinetics of foodborne pathogens: In silico ADMET studies of major compounds

The peels of citrus fruit are always discarded as waste and cause environmental pollution. The waste citrus peels can be used to extract essential oils which are environmental friendly, cost effective and natural alternative to chemical agents to inhibit foodborne pathogens. Essential oils are mixture numerous biologically active compounds which has many biological properties like antimicrobial, antioxidant and often use as food preservative. In current study the effects of essential oils of citrus varieties mainly PL1, PL2, PL3 and PL4 were evaluated against Bacillus cereus MTCC430 and Yersinia enterocolitica MTCC859 and found that oils were affecting the growth kinetics of bacterial strains at MIC, 1/2MIC and 1/4MIC concentrations. The yields of essential oils were found to be PL1: Citrus jambhiri followed by PL4: Citrus aurantifolia (rough lemon), PL3: Citrus limon (elongated) and PL2: Citrus medica that is 7.5%, 6.2%, 5.3% and 3.5% respectively. The ADMET profiling showed safety of the selected compounds with better bioavailability score and good brain penetration. The vast possibilities of bioresources of North East India need to be explored. published by the Journal of Biodiversity and Environmental Sciences | JBES