The subacute toxicity of silver nanoparticles on some immunology and physiology responses in Shabut (Tor grypus)

The present study aimed to determine the acute and subacute toxicity and evaluate the effects of subacute concentrations (10%, 20%, 40%, and 80% of 96-h lethal concentration 50 of nanoparticles silver; 0.0 as control, 0.012, 0.025, 0.05, and 0.101 mg/L) of silver nanoparticles on some immunology and physiology responses of Shabut (Tor grypus) after 0, 7, 14, 21, and 28 days of exposure. The results showed that the total white blood cell counts and lysozyme activity were significantly higher in silver nanoparticle-exposed groups (P<0.05). The hemoglobin values in 10% and serum bactericidal in 20% and 40% of 96-h lethal concentration 50 of silver nanoparticles exposed groups were significantly higher compared to the control group (P<0.05). A significant increase was observed in the serum levels of alanine aminotransferase in the 40% and 80% silver nanoparticles exposed groups (P<0.05). Aspartate aminotransferase levels in the 10% silver nanoparticles exposed group were significantly higher compared to the control group (P<0.05). Results suggest that silver nanoparticles induce alterations in the serum biochemical and immunology parameters and stress responses in Shabut (Tor grypus).