Origami paper-based biosensor to SARS CoV-2 on the surface

The European project RELIANCE aims to create modified self-disinfecting surfaces as a way to control the spread of pathogens better. In this context, we present a paper origami electrochemical sensor that we are developing, which can measure the effectiveness of the specific surface modification. Following up on our previously published work, which was the first publication describing an electrochemical immunosensor for SARS-CoV-2 detection in saliva, we adapted the sensor to easily detect the virus on the surface. The method uses the magnetic beads as support for the sandwich-type immunological chain, which, thanks to their high surface/volume ratio, permits the load of a high amount of antibodies, improving the assay sensitivity. Currently, our work is refining the design of the sensor origami model by selecting the type of paper to use.