Neuroinflammatory markers with immunoreactivity indicators in children with cerebral palsy

The purpose of the study was to assess the diagnostic significance of the S100 protein, hematological and immunological indicators in children with cerebral palsy (CP). The sample included both male and female children who underwent measurement of S100 protein, hemoglobin, leukocytes, platelets, ESR, and immunoglobulins A, M, and G. Statistical analysis included calculation of means, standard errors, confidence intervals, and ROC analysis. Girls demonstrated significantly higher S100 protein levels compared to boys, indicating greater glial reactivity. A trend toward higher IgM levels in girls suggested a more active primary immune response, requiring dynamic evaluation in relation to intercurrent infections. These findings highlight the clinical importance of S100 and MCP-1 as biomarkers of neuroinflammation and immune reactivity in cerebral palsy, providing insights for individualized neurorehabilitation strategies.