A Review on Role of HSP70 in Treatment of Cancer

HSP 70 (Heat shock proteins) are an old defense mechanism found in all species. By facilitating the correct folding and refolding of misfolded proteins and aiding in the removal of aged and damaged cells, these proteins function as molecular chaperons Hsp100, Hsp90, Hsp70, Hsp40 and tiny heat shock proteins are example of heat shock proteins. Heat shock protein 70 interact with a broad range of molecules, including unfolded, natively folded, and aggregated proteins, through its substrate binding domains and offers cytoprotection against a variety of cellular stressors. High levels of Hsp70 expression enable cells to endure fatal wounds under pathological circumstances. Increased Hsp70 inhibits apoptosis by interfering with many apoptotic signaling pathways.