A cautionary note on the naive use of general-population biobanks to study pulmonary arterial hypertension, with a focus on Mendelian randomisation.

There are two issues with using existing data from general-population biobanks to study PAH: low power and non-random misclassification. Relative to gold standard data, this results in false-positive and false-negative findings. https://bit.ly/4nksm6c

Publication Details

Journal
Apollo (University of Cambridge)
Published
2025-09-04
DOI
https://doi.org/10.17863/cam.121079
Primary Topic
Geochemistry and Geologic Mapping
Type
article
Field-Weighted Citation Impact
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article

A cautionary note on the naive use of general-population biobanks to study pulmonary arterial hypertension, with a focus on Mendelian randomisation.

Apollo (University of Cambridge)
Geochemistry and Geologic Mapping
article

A cautionary note on the naive use of general-population biobanks to study pulmonary arterial hypertension, with a focus on Mendelian randomisation.

article en

Abstract

There are two issues with using existing data from general-population biobanks to study PAH: low power and non-random misclassification. Relative to gold standard data, this results in false-positive and false-negative findings. https://bit.ly/4nksm6c

Apollo (University of Cambridge)
Openalex Percentile: Top 54%
Geochemistry and Geologic Mapping
DOIOpen Access PDFOpenAlex
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A cautionary note on the naive use of general-population biobanks to study pulmonary arterial hypertension, with a focus on Mendelian randomisation. · Apollo (University of Cambridge) (2025) | TGRS Research Map | TGRS