PLGA- BASED DRUG DELIVERY: UNRAVELING THE POTENTIAL OF NANOFIBERS AND MICROSPHERES

Abstract: The FDA has fully studied and approved poly (lactic-co-glycolic acid) (PLGA), a biodegradable polymer. It is known for having a wide range of physicochemical properties, being very biocompatible, and being able to break down at different rates. PLGA-based drug delivery systems have become very popular because of their unusual structural and functional properties, which are found in nanofibers and microspheres. PLGA Nanofibers, which are usually made by electrospinning, have a high surface area-to-volume ratio and look like the extracellular matrix. This makes them great for tissue engineering and for releasing drugs in a specific area over a long period of time. PLGA microspheres, on the other hand, are made using methods like solvent evaporation or spray drying. They let you control the speed at which drugs are released very precisely and are great for both localized and systemic delivery.This review talks about the different parts of drug delivery systems, such as their features, how they are made, how drugs are loaded and released, their uses, benefits, problems, and what might happen in the future. But there are still problems, like making sure that medications are evenly distributed, being able to scale up production, and controlling release profiles very precisely. Recent developments in modifying copolymers, adding functional groups to surfaces, and adding components that respond to stimuli show that these problems can be solved. It is thought that combining PLGA-based systems with advanced biomaterials and nanotechnology will make it easier to create personalized and next-generation drug delivery systems in the future. In general, PLGA Nanofibers and Microspheres are known to be very flexible and useful carriers in the fields of pharmaceuticals and biomedicine that are growing quickly. Keywords: Poly (lactic-co-glycolic acid) (PLGA) drug delivery, Nanofibers, Microshpers, Electrospinning.