Evaluation Of Igg Elisa in Radiologically Positive and Negative Cases of Neurocysticercosis at A Tertiary Care Hospital in Western Uttar Pradesh: A Cross-Sectional Study

Introduction: One of the most prevalent infections of the human neurological system is neurocysticercosis. Most of the world is affected by this disease. The diagnosis of neurocysticercosis (NCC), where the survival of the parasite is a major determinant, and is challenging due to the variety of clinical manifestations and the course of the disease. This study evaluates ELISAs for the detection of anti-Taenia solium metacestode IgG antibodies in serum utilizing T.solium antigens. Aim: To evaluate CT-positive cases against IgG ELISA to determine the utility of antibody ELISA and/or antigen ELISA in the diagnosis of neurocysticercosis cases at UPUMS, Saifai, Etawah, (U.P.) The primary goal is to diagnose NCC cases by using the antibody ELISA at UPUMS Saifai. Materials and methods: 100 patients who had symptoms and radiological findings strongly suggestive of NCC made up the study group. T. solium IgG ELISA was used to identify anti-T. solium antibodies. Results: The most frequent complaint among new patients was seizures. In many studies of IgG antibodies against cysticerci by ELISA, researchers have found 17% seropositivity and 83% of patients tested negative for clinical and radiological characteristics of NCC. This demonstrates the diagnostic sensitivity of ELISA for NCC. The sensitivity of the IgG-antigen-based ELISA is 30%. In contrast, the specificities of the ELISA were 96% for IgG antibody detection in serum, 60.57% for PPV, 87% for NPV, and 63% for accuracy when antigen was used