Incidence, Risk Factors, And Microbial Spectrum Of Central Line-Associated Bloodstream Infections In ICU Patients: A Prospective Observational Study

Background: Central venous catheterization is commonly performed in intensive care units (ICUs), providing essential vascular access but posing a risk of bloodstream infections. This study evaluates the incidence and microbial profile of central line-associated bloodstream infections (CLABSI) in critically ill patients. Material and Methods: 150 ICU patients requiring central venous catheters were observed. Relevant investigations were performed before and 48 hours after insertion. In suspected infections, clinical evaluations and laboratory tests were conducted to rule out other sources and confirm CLABSI. Results: Among 150 patients (mean age 42.1±14.3 years), CLABSI/CRBSI was identified in 52 cases (34.6%). Fever was the most common sign (80.8%), followed by tachypnea (76.9%) and hypotension (63.5%). The most frequently isolated organism was Staphylococcus aureus (34.6%). Femoral access and prolonged catheter days were significantly associated with infection. Conclusions: Proper aseptic techniques and catheter care can significantly reduce CLABSI risk. Identification of high-risk factors aids in improving patient outcomes