DEVELOPMENT AND EVALUATION OF EXTENDED-RELEASE ACEMETACIN CAPSULES USING COMBINED DRY AND WET GRANULATION METHODS

Acemetacin is a non-steroidal anti-inflammatory drug and the carboxymethyl ester of indometacin. There are many generic drugs of acemetacin on the market but there are only two dosage forms. Those dosage forms are direct effect capsules and extended relaese capsules. The manufacturing process is different in both dosage forms. In this study we tried manufacturing the capsules with different methods. After testing dissolution profiles, we tried to find the best way to manufacture acemetacin capsules.