Formulation, Characterization, and Evaluation of an Herbal Hydrogel Composed of Aloe Vera and Flaxseed (Linum usitatissimum): A Multifunctional Skincare System

The modern skincare and cosmeceutical industries are experiencing a paradigm shift toward plant-based, eco-friendly formulations. Among emerging topical systems, hydrogels offer exceptional potential for drug and cosmetic delivery due to their ability to retain moisture, enhance skin penetration, and stabilize active ingredients. This research focuses on the development and evaluation of a herbal hydrogel formulated using two traditional plant-based ingredients: Aloe vera and L.usitatissimum (flaxseed). Both components are individually known for their anti-inflammatory, antioxidant, and skin-soothing properties. Their combination into a hydrogel matrix provides a unique platform that supports wound healing, moisturization, and protection against oxidative damage. The hydrogel was prepared using standardized extraction techniques and formulated using a combination of natural and semi-synthetic gelling agents. Various physicochemical parameters such as pH, viscosity, spreadability, stability, and drug content uniformity were assessed. Advanced spectroscopic and in vitro release studies confirmed the chemical compatibility and sustained release profile of the active ingredients. Microbial safety and antioxidant potential were confirmed through antimicrobial load tests and DPPH assays. The optimized hydrogel exhibited favorable characteristics, such as a pH range compatible with the skin (5.5–6.5), high viscosity (4800–6500 cP), uniform drug distribution (98.2 ± 1.5%), excellent spreadability (6.2 ± 0.3 cm), and a significant in vitro drug release (~98.2% over 24 hours). These results confirm the formulation's stability, efficacy, and potential for topical therapeutic and cosmetic applications. This study underscores the synergistic potential of Aloe vera and flaxseed in a hydrogel base and contributes to the growing body of research supporting natural alternatives in dermal therapeutics.