A Review on Self Assembling Cyclodextrin Hydrogels

Cyclodextrin (CD)-based self-assembling hydrogels have gained significant devotion in biomedical, pharmaceutical, and material science due to their unique ability to form stable supramolecular structures through host–guest interactions. The hydrophilic exterior and hydrophobic cavity of CDs enable the encapsulation of various guest molecules, leading to stimuli-responsive, biocompatible, and tunable hydrogels. Because of their porous nature, hydrogels are used extensively in the biomedical and material sciences. Cyclodextrin (CD), a naturally occurring oligosaccharide, has demonstrated exceptional potential for use in the production and use of hydrogels. CD may be added to hydrogels to create networks that are physically or chemically cross-linked. Additionally, CD is a perfect carrier for delivering active substances into target tissues due to its distinctive cavity shape. This review outlines practical techniques for creating hydrogels that include CDs. The possible biological uses of hydrogels containing CD are also examined. It is addressed how CD-containing hydrogels leak and degrade under various circumstances. Lastly, a presentation of the present issues and potential avenues for further study on hydrogels containing CD is made.