GENRE-CMR: Generalizable Deep Learning for Diverse Multi-Domain Cardiac MRI Reconstruction

Accelerated Cardiovascular Magnetic Resonance (CMR) image reconstruction remains a critical challenge due to the trade-off between scan time and image quality, particularly when generalizing across diverse acquisition settings. We propose GENRE-CMR, a generative adversarial network (GAN)-based architecture employing a residual deep unrolled reconstruction framework to enhance reconstruction fidelity and generalization. The architecture unrolls iterative optimization into a cascade of convolutional subnetworks, enriched with residual connections to enable progressive feature propagation from shallow to deeper stages. To further improve performance, we integrate two loss functions: (1) an Edge-Aware Region (EAR) loss, which guides the network to focus on structurally informative regions and helps prevent common reconstruction blurriness; and (2) a Statistical Distribution Alignment (SDA) loss, which regularizes the feature space across diverse data distributions via a symmetric KL divergence formulation. Extensive experiments confirm that GENRE-CMR surpasses state-of-the-art methods on training and unseen data, achieving 0.9552 SSIM and 38.90 dB PSNR on unseen distributions across various acceleration factors and sampling trajectories. Ablation studies confirm the contribution of each proposed component to reconstruction quality and generalization. Our framework presents a unified and robust solution for high-quality CMR reconstruction, paving the way for clinically adaptable deployment across heterogeneous acquisition protocols.